An uneducated collector for a Philadelphia loan shark is given a once-in-a-lifetime opportunity to fight against the world heavyweight boxing champion.

When former Green Beret John Rambo is harassed by local law enforcement and arrested for vagrancy, he is forced to flee into the mountains and wage an escalating one-man war against his pursuers.

Ray Breslin is the world's foremost authority on structural security. After analyzing every high security prison and learning a vast array of survival skills so he can design escape-proof prisons, his skills are put to the test. He's framed and incarcerated in a master prison he designed himself. He needs to escape and find the person who put him behind bars.

Barney Ross leads a band of highly skilled mercenaries including knife enthusiast Lee Christmas, a martial arts expert Yin Yang, heavy weapons specialist Hale Caesar, demolitionist Toll Road, and a loose-cannon sniper Gunner Jensen. When the group is commissioned by the mysterious Mr. Church to assassinate the dictator of a small South American island, Barney and Lee visit the remote locale to scout out their opposition and discover the true nature of the conflict engulfing the city.