One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.

Near a gray and unnamed city is the Zone, a place guarded by barbed wire and soldiers, and where the normal laws of physics are victim to frequent anomalies. A stalker guides two men into the Zone, specifically to an area in which deep-seated desires are granted.