1876. The Black Hills Indian Cession, two weeks after Custer's last stand. Witness the birth of an American frontier town – and the ruthless power struggle between its just and unjust pioneers. In an age of plunder and greed, the richest gold strike in American history draws a mob of restless misfits to an outlaw settlement where everything – and everyone – has a price. The settlers, ranging from an ex-lawman to a scheming saloon owner to the legendary Wild Bill Hickok and Calamity Jane, share a constant restlessness of spirit, and survive by any means necessary. Welcome to Deadwood... a hell of a place to make your fortune.

As the west rapidly becomes civilized, a pair of outlaws in 1890s Wyoming find themselves pursued by a posse and decide to flee to South America in hopes of evading the law.

Two jobless Americans convince a prospector to travel to the mountains of Mexico with them in search of gold. But the hostile wilderness, local bandits, and greed all get in the way of their journey.

Two bounty hunters both pursue a brutal and sadistic bandit El Indio who has a massive bounty on his head.

The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter. When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.

A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.

In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.

Wounded Civil War soldier John Dunbar tries to commit suicide—and becomes a hero instead. As a reward, he's assigned to his dream post, a remote junction on the Western frontier, and soon makes unlikely friends with the local Sioux tribe.

With the help of a German bounty hunter, a freed slave sets out to rescue his wife from a brutal Mississippi plantation owner.

While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.