Set in the year 2000, when the level of Labor accidents begin to escalate around Tokyo Bay, police detectives Kusumi and Hata are assigned to investigate. What they discover leads to a series of government cover-ups, conspiracy concerning a new biological weapon entitled WXIII-Wasted Thirteen and a tragic, personal connection to Hata. The only hope to stop this threat is to cooperate with the military and lead WXIII into a showdown with the Labors of Special Vehicle Division 2.

A Japanese police unit who use giant anthropomorphic robots (called Labors) is caught up in a political struggle between the civilian authorities and the military when a terrorist act is blamed on an Air Force jet. With the aid of a government agent, the team gets close to a terrorist leader to stop things from going out of control when after the military is impelled to impose martial law.

故事背景为徳川幕府时期，一只双尾巨猫忽然现身江户城中，大肆作乱，引起恐慌。“画仙道”的长老十文字得知此为“画兽”，他察觉到这次画兽作乱事件，极有可能是企图造反的地下组织的阴谋，遂请求门生墨屋纸朗（中尾明庆 配音）前来江户调查。
画仙道术一门的门生，都拥有一种特殊能力，能够运用绘画和书法击退画兽。纸卷（浪川大辅 配音）和绘名（古川小百合 配音）就是其中优秀的门生，加上佼佼者纸朗，三名“画仙道”门生与强大的“画兽”进行战斗，他们能否粉碎谋反派的阴谋？
本动画同名脚本从1200多部作品中脱颖而出，荣获第七届的Animax大赏。