The spirited Boruto Uzumaki, son of Seventh Hokage Naruto, is a skilled ninja who possesses the same brashness and passion his father once had. However, the constant absence of his father, who is busy with his Hokage duties, puts a damper on Boruto's fire. He ends up meeting his father's friend Sasuke, and requests to become... his apprentice!? The curtain on the story of the new generation rises!

Demons that once almost destroyed the world, are revived by someone. To prevent the world from being destroyed, the demon has to be sealed and the only one who can do it is the shrine maiden Shion from the country of demons, who has two powers; one is sealing demons and the other is predicting the deaths of humans. This time Naruto's mission is to guard Shion, but she predicts Naruto's death. The only way to escape it, is to get away from Shion, which would leave her unguarded, then the demon, whose only goal is to kill Shion will do so, thus meaning the end of the world. Naruto decides to challenge this "prediction of death."

After his capture for attempted assassination of the Raikage, leader of Kumogakure, as well as killing Jōnin from Kirigakure and Iwagakure, Naruto is imprisoned in Hōzukijou: A criminal containment facility known as the Blood Prison. Mui, the castle master, uses the ultimate imprisonment technique to steal power from the prisoners, which is when Naruto notices his life has been targeted. Thus begins the battle to uncover the truth behind the mysterious murders and prove Naruto's innocence.