Ethan and team take on their most impossible mission yet—eradicating 'The Syndicate', an International and highly-skilled rogue organization committed to destroying the IMF.

Ethan Hunt and his team are racing against time to track down a dangerous terrorist named Hendricks, who has gained access to Russian nuclear launch codes and is planning a strike on the United States. An attempt to stop him ends in an explosion causing severe destruction to the Kremlin and the IMF to be implicated in the bombing, forcing the President to disavow them. No longer being aided by the government, Ethan and his team chase Hendricks around the globe, although they might still be too late to stop a disaster.

Ethan Hunt and the IMF team continue their search for the terrifying AI known as the Entity — which has infiltrated intelligence networks all over the globe — with the world's governments and a mysterious ghost from Ethan's past on their trail. Joined by new allies and armed with the means to shut the Entity down for good, Hunt is in a race against time to prevent the world as we know it from changing forever.