After the re-emergence of the world's first mutant, world-destroyer Apocalypse, the X-Men must unite to defeat his extinction level plan.

The ultimate X-Men ensemble fights a war for the survival of the species across two time periods as they join forces with their younger selves in an epic battle that must change the past – to save our future.

Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker. Storm, Wolverine and Jean Grey must join their usual nemeses—Magneto and Mystique—to unhinge Stryker's scheme to exterminate all mutants.

Two mutants, Rogue and Wolverine, come to a private academy for their kind whose resident superhero team, the X-Men, must oppose a terrorist organization with similar powers.

The X-Men face their most formidable and powerful foe when one of their own, Jean Grey, starts to spiral out of control. During a rescue mission in outer space, Jean is nearly killed when she's hit by a mysterious cosmic force. Once she returns home, this force not only makes her infinitely more powerful, but far more unstable. The X-Men must now band together to save her soul and battle aliens that want to use Grey's new abilities to rule the galaxy.

When a cure is found to treat mutations, lines are drawn amongst the X-Men—led by Professor Charles Xavier—and the Brotherhood, a band of powerful mutants organised under Xavier's former ally, Magneto.

在《X战警》漫画中，X特工队（X-Force）隶属于X战警。他们与正面形象示人的镭射眼等人不同，擅长用一些极端、残暴的方式与敌人对抗，为了保护变种人的生命勇往直前。主要成员包括金刚狼、X-23（金刚狼的克隆体）、印第安战士Warpath、具有高度飞行能力的Archange l以及拥有变身能力的Wolfsbane。据传闻称来自未来的镭射眼之子Cable和他的好友Deadpool会在电影中扮演重要角色。