Yu-jin and her blind mother move to a small village from Seoul. On her first day at the new school, Yu-jin gets picked on by her classmates. Along with other victims of hatred, Yu-jin puts a curse on the four girls tormenting them through a Ouija Board. On her second day at school, one of the spellbound bursts into flames and dies just as she sits down where Yu-jin used the board. Next day, another victim burns to death, and now the school is enclosed by horror.

Colic is a syndrome found in infants, which causes infants to cry continuously for hours. The reason behind this illness is usually credited by medical expects to a number of factors. However, some people believe that it's linked to something supernatural.

矶部一家六口人搬到新的房子，自搬入之日起，矶部家次子笃平的性情便开始发生转变。随着又一次司法考试的失败，笃平在圣诞前夜将母亲、兄长、嫂子以及两个侄女残忍杀害，随后带着小侄女未来的头颅来到深山野岭，上吊自杀。死前留下了录有古怪留言的录音带。
凶案发生第二天，快递员田宫（铃木裕树 饰）送货至矶部家，在一系列诡异事件后，他发现了凶案现场，却从此被拿着篮球的白色老女的怨灵所纠缠；由于怨灵作祟，未来的小学同学小茜也在凶案次日失去了父亲（宫川一朗太 饰）。这起灭门惨案至此告一段落，但在七年之后，已经上了高中的小茜（南明奈 饰）再次被带回旧日的噩梦之中……
本片为日本恐怖片《咒怨》系列的十周年纪念作品第一部，另一部名为《黑少女》。

The supernatural grudge manifests itself by way of a strange cyst growing in the body of a young woman, slowly draining all life from her in revenge for... what?