Video game bad guy Ralph and fellow misfit Vanellope von Schweetz must risk it all by traveling to the World Wide Web in search of a replacement part to save Vanellope's video game, Sugar Rush. In way over their heads, Ralph and Vanellope rely on the citizens of the internet — the netizens — to help navigate their way, including an entrepreneur named Yesss, who is the head algorithm and the heart and soul of trend-making site BuzzzTube.

十年冷战后，Scrooge McDuck 被找来照顾三个侄子 Huey，Dewey 和 Louie 时，再次与他疏远的侄子 Donald Duck 团聚。新来者重新激发了 Scrooge 的冒险意识，他邀请四人与他、管家 Beakley 太太和她的孙女 Webby Vanderquack 一起住在麦克杜克庄园。他们一起参加了许多新的寻宝探险和环球旅行冒险，同时与诸如Flintheart Glomgold，Beagle Boys 和 Mark Beaks 等恶棍竞争。