Terminal Island, New York: 2020. Overcrowding in the US penal system has reached a breaking point. Prisons have been turned over to a monolithic Weyland Corporation, which sees jails full of thugs as an opportunity for televised sport. Adrenalized inmates, a global audience hungry for violence and a spectacular, enclosed arena come together to form the 'Death Race', the biggest, most brutal event.

Former Special Forces officer Frank Martin will deliver anything to anyone for the right price, and his no-questions-asked policy puts him in high demand. But when he realizes his latest cargo is alive, it sets in motion a dangerous chain of events. The bound and gagged Lai is being smuggled to France by a shady American businessman, and Frank works to save her as his own illegal activities are uncovered by a French detective.