An uneducated collector for a Philadelphia loan shark is given a once-in-a-lifetime opportunity to fight against the world heavyweight boxing champion.

Barney Ross leads a band of highly skilled mercenaries including knife enthusiast Lee Christmas, a martial arts expert Yin Yang, heavy weapons specialist Hale Caesar, demolitionist Toll Road, and a loose-cannon sniper Gunner Jensen. When the group is commissioned by the mysterious Mr. Church to assassinate the dictator of a small South American island, Barney and Lee visit the remote locale to scout out their opposition and discover the true nature of the conflict engulfing the city.