Columbus has made a habit of running from what scares him. Tallahassee doesn't have fears. If he did, he'd kick their ever-living ass. In a world overrun by zombies, these two are perfectly evolved survivors. But now, they're about to stare down the most terrifying prospect of all: each other.

After a zombie becomes involved with the girlfriend of one of his victims, their romance sets in motion a sequence of events that might transform the entire lifeless world.

小室孝（诹访部顺一 配音）就读于私立藤美学园高中午2年级，这一日，他正享受着校园悠闲而平静的生活，突然间，一个异物的闯入令学校成为了上演着鲜血和惨剧的舞台。一种被称之为“死体”的怪物包围了校园，它们狂暴嗜血，且拥有不可摧毁的肉体。通过好友井豪永（宫野真守 配音）的牺牲， 小室孝吃惊的发现，所有被这些怪物咬伤或咬死的人们，都将面临变异为死体的命运，而消灭它们的唯一方法，即是破坏它们的头部。 为了争取生存的权利，为了保护所爱的人，小室孝不得不拿起武器开始战斗。亲梅竹马宫本丽（井上麻里奈 配音），剑道高手毒岛冴子（泽城美雪 配音），外表坚强内心脆弱的大小姐高城沙耶（喜多村英梨 配音），这些昔日的同学现今的战友，他们能够顺利的抵达安全地带吗？

Life for former United Nations investigator Gerry Lane and his family seems content. Suddenly, the world is plagued by a mysterious infection turning whole human populations into rampaging mindless zombies. After barely escaping the chaos, Lane is persuaded to go on a mission to investigate this disease. What follows is a perilous trek around the world where Lane must brave horrific dangers and long odds to find answers before human civilization falls.

On July 15, the Ghost Gate opens and spirits wander the world. Taoist master Uncle Chiu prepares rituals, but his disciple Wanchai sneaks off to a ghost play and is charmed by the wandering spirit Li. Charleston goes to save him, but also falls for her, and together they unleash the ghosts. To set things right, Uncle Chiu calls on his colleague, Master Kin, but trouble grows when Wanchai and Charleston accidentally kill Kin’s corrupt disciple, who turns out to be his secret son. Kin resurrects him as a bloodsucking vampire to seek revenge.