Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.

An average family is thrust into the spotlight after the father commits a seemingly self-defense murder at his diner.

After getting into a serious car accident, a TV director discovers an underground sub-culture of scarred, omnisexual car-crash victims, and he begins to use car accidents and the raw sexual energy they produce to try to rejuvenate his sex life with his wife.