When an IMF mission ends badly, the world is faced with dire consequences. As Ethan Hunt takes it upon himself to fulfill his original briefing, the CIA begin to question his loyalty and his motives. The IMF team find themselves in a race against time, hunted by assassins while trying to prevent a global catastrophe.

Fuelled by his restored faith in humanity and inspired by Superman's selfless act, Bruce Wayne and Diana Prince assemble a team of metahumans consisting of Barry Allen, Arthur Curry and Victor Stone to face the catastrophic threat of Steppenwolf and the Parademons who are on the hunt for three Mother Boxes on Earth.