Several years after his last adventure, retired fortune hunter, Nathan Drake, is forced back into the world of thieves. With the stakes much more personal, Drake embarks on a globe-trotting journey in pursuit of a historical conspiracy behind a fabled pirate treasure. His greatest adventure will test his physical limits, his resolve, and ultimately what he's willing to sacrifice to save the ones he loves. Several years after his last adventure, Nathan Drake has retired from fortune hunting and settled into a quiet life with his wife Elena. When his long-lost brother Sam, presumed dead for fifteen years, reappears claiming he needs help finding the treasure of pirate Henry Avery to pay off a dangerous debt, Nate is pulled back into his old life. Aided by longtime partner Sully, the Drake brothers follow a trail of clues from Italy to Madagascar and Scotland, pursued by wealthy rival treasure hunter Rafe Adler and his private military force. The search leads them toward Libertalia, a legendary pirate colony, where Nate must confront the cost of obsession and decide what he is willing to sacrifice for one last score.

《神秘海域：德雷克合集》是ps3经典游戏《神秘海域》系列的重制版，将包括《神秘海域：德雷克的宝藏》、《神秘海域：盗亦有道》、《神秘海域：德雷克的诡计》3款作品的单人故事游戏部分，而无多人联机游戏内容。该游戏合集将以1080P/60FPS的画面运行，对游戏贴图材质及光照进行大幅度增强。