After the shocking events of the Season 2 finale, Hannibal is on the run in Europe - accompanied by his psychiatrist Bedelia Du Maurier - sporting a new identity, but servicing the same insatiable appetite. As the lives of Will, Jack and Alana converge toward Hannibal again, each with their own motivations to catch him once and for all, their deadly dance turns in startling and unexpected ways.

After being sworn in by Jack Crawford, the head of the FBI Behavioral Science Unit, to help capture a serial killer who is on the rampage, Will finds himself increasingly struggling to control his thought processes that inform his uncanny ability to empathise with serial killers. When damning evidence shows up at the FBI that implicates Will in a string of grisly murders he is immediately placed under the care of the Baltimore State Hospital for the Criminally Insane. As Will tries to assure Jack of his innocence he also attempts to convince him of the identity of the real killer.

After a particularly grueling case hunting a serial killer known as the Minnesota Shrike, Will Graham threatens to walk away. Jack Crawford, the head of the FBI's Behavioral Science Unit, desperately needs Will on his team to break the tough cases, so he enlists Dr. Hannibal Lecter, to ensure Will's mental well-being. Unbeknownst to Will, Hannibal also has a particular insight into these horrible crimes and the psychopaths who commit them. As Will hunts down brutal killers, he is unknowingly sitting across from the most gifted killer of them all.

这家酒吧叫Horace and Pete，开了一百年，这一个世纪由历代的Horace和Pete来经营。这家年迈的酒馆在光鲜的布鲁克林似乎已经过气了，现在的主人也如同这家疲倦的酒馆一样。Horace离过婚，没有固定女友，跟子女处理不好关系；Pete一辈子都在这家酒吧里，有精神疾病，一旦停药就会失控。还有他们的叔叔、姐姐、前妻、爷爷的前女友、不定期的床伴以及定期的老顾客，构成了属于这家酒馆的百年江湖。