Trapped in their New York brownstone's panic room, a hidden chamber built as a sanctuary in the event of break-ins, newly divorced Meg Altman and her young daughter Sarah play a deadly game of cat-and-mouse with three intruders - Burnham, Raoul and Junior - during a brutal home invasion. But the room itself is the focal point because what the intruders really want is inside it.

A radio astronomer receives the first extraterrestrial radio signal ever picked up on Earth. As the world powers scramble to decipher the message and decide upon a course of action, she must make some difficult decisions between her beliefs, the truth, and reality.