In the summer of 1983, a 17-year-old Elio spends his days in his family's villa in Italy. One day Oliver, a graduate student, arrives to assist Elio's father, a professor of Greco-Roman culture. Soon, Elio and Oliver discover a summer that will alter their lives forever.

Paris, in the early 1990s: a group of young activists is desperately tied to finding the cure against an unknown lethal disease. They target the pharmaceutical labs that are retaining potential cures, and multiply direct actions, with the hope of saving their lives as well as the ones of future generations.