2199 AD. Yamato tried to leave behind the Large Magellanic Cloud galaxy, after receiving a "Cosmo Reverse System" at its destination, Iscandar. However, suddenly, it encounters a mysterious group at the edge of the Large Magellanic Cloud. The crew finds out that the group is called the "Gatlantis," and that its leader is the Gutaba expeditionary force commander who calls himself "Goran Dagaamu of Thunder." The commander demands that Yamato be handed over to him. Yamato, wanting to hurry to Earth, escapes the fray. However, Yamato is attacked by a devastating beam weapon called the "Flame Direct Attack Cannon" that can transcend space.

围绕“大和”与“缘”的人们的故事，即将迎来新的局面。 到达传说的行星特雷萨特的大和号，等着他们的不只有女神特蕾莎而已。 在古代等人的面前出现的是因缘的对手——曾经的仇敌德斯拉。大和号与集合了卡米拉斯旧体制派的德斯拉舰队交战。 此时，赶往古代等人身边的奇曼采取的惊人行动是——。 另一方面，新的萨贝拉在加特兰蒂斯觉醒，正式的地球侵略作战终于开始。 企图歼灭各种文明、生命的加特兰蒂斯，与以旗舰安德洛墨达为中心的波动炮舰队激烈冲突。 沉睡在巨大白色彗星深处的都市帝国的真正姿态是？以及由佐达提出的新的恶魔的选择…… 最后五分钟——伴着眼泪，你将目睹冲击性的结局。

《宇宙战舰大和号2199》的续集第四章《宇宙战舰大和号 爱的战士们 第四章 天命篇》确定将于2018年1月27日上映。