Ashitaka, a prince of the disappearing Emishi people, is cursed by a demonized boar god and must journey to the west to find a cure. Along the way, he encounters San, a young human woman fighting to protect the forest, and Lady Eboshi, who is trying to destroy it. Ashitaka must find a way to bring balance to this conflict.

Takashi Natsume has grown accustomed to his encounters with youkai through the Book of Friends, which contains the names of youkai whom his grandmother, Reiko Natsume, has sealed in contracts. These encounters allow Natsume to better understand the youkai, Reiko, and himself. The Book of Friends is a powerful tool that can be used to control youkai; it is sought after by both youkai and exorcists alike. Natsume just wants to live out his daily life in peace but is constantly disrupted by these experiences. If he is to end this torment, Natsume must explore more about the book and the world of exorcism, as well as begin to open his heart to those who can help him.

The movie of Natsume's Book of Friends series. Natsume has been busy, navigating between humans and Yokai when he coincidentally reunites with an old classmate, Yuki. It brings back painful memories of a certain Yokai. Meanwhile, Natsume also became acquainted with Yorie Tsumura, a woman in the memories of a Yokai whose name he had returned. Yorie knew much about Reiko, but now lived a peaceful life with her only son, Mukuo. Being with this family was comforting for Natsume, but apparently a mysterious Yokai has been lurking in their town. On the way back from investigating, a "Yokai seed" that had latched itself to Nyanko Sensei drops into the Fujiwaras' garden and grows overnight into a fruit tree. When Nyanko Sensei eats a fruit that is somehow shaped like himself, he suddenly splits into three!

岩仓玲音的同学四方田千砂自杀了。没有任何前兆的自杀事件让同学们不知所措，一周后，玲音收到了千砂的短信。明明已死的千砂居然以手机短信和玲音开始了交流。回到家，玲音用爸爸给她的电脑开始与千砂联系。当谈及为何自杀时，千砂回答说“因为我已经不需要身体了，没有身体，我可以在wired网络之间继续活着。”不解的玲音继续调查千砂的事件，发现wired网络之中隐藏的巨大秘密，玲音自己的身世也出现了谜团。玲音面对网络世界中的真相，耳边不断响起千砂的话“我生存在wired中，因为神在那里。”