Yato and Yukine have finally mended their relationship as god and Regalia. As a minor and unknown deity, Yato continues to take odd jobs for five yen apiece in hopes of one day having millions of worshippers and his own grand shrine. He has yet to fix Hiyori Iki's loose soul, but she cheerily prepares for high school nonetheless.

In times of need, if you look in the right place, you just may see a strange telephone number scrawled in red. If you call this number, you will hear a young man introduce himself as the Yato God. Yato is a minor deity and a self-proclaimed "Delivery God," who dreams of having millions of worshippers. Without a single shrine dedicated to his name, however, his goals are far from being realized. He spends his days doing odd jobs for five yen apiece, until his weapon partner becomes fed up with her useless master and deserts him.

Takashi Natsume, the timid youkai expert and master of the Book of Friends, continues his journey towards self-understanding and acceptance with the help of friends both new and old.

Natsume, while briefly separated from Nyanko-sensei, is ambushed and kidnapped by a strange group of masked, monkey-like youkai, who have spirited him away to their forest as they desperately search for the Book of Friends. Realizing that his "servant" has been taken out from right under his nose, Nyanko-sensei enlists the help of Natsume's youkai friends and mounts a rescue operation. However, the forest of the monkey spirits holds many dangerous enemies, including the Matoba Clan, Natsume's old nemesis.

Stretching from the formidable hideout of the Matoba to Natsume's own childhood home, Natsume Yuujinchou Shi is a sweeping but familiar return to a world of danger and friendship, where Natsume will finally confront the demons of his own past.

Natsume Yuujinchou San follows Takashi Natsume, a boy who is able to see youkai. Natsume and his bodyguard Madara, nicknamed Nyanko-sensei, continue on their quest to release youkai from their contracts in the "Book of Friends."

Natsume comes to terms with his ability to see youkai and stops thinking of it as a curse. As he spends more time with his human and youkai friends, he realizes how much he values them both and decides he doesn't have to choose between the spirit and human worlds to be happy.

As with its prequel, Zoku Natsume Yuujinchou is about Takashi Natsume, a boy who has had the ability to see youkai since he was young, and his bodyguard youkai Madara, nicknamed Nyanko-sensei. Natsume attempts to return names written in his "Book of Friends" (which he inherited from his grandmother Reiko) to youkai in his village. Throughout these adventures, he meets some youkai that are friendly, some that want to steal the Book, and some that want to kill him, as Natsume learns about himself and his relationship with these mysterious beings along the way.

Due to an unusual ability to see strange creatures called youkai, Takashi Natsume has never fit in. Over time, he has accepted that no one would ever believe him and has closed himself.

When Natsume accidentally breaks an intangible barrier, he frees Madara—a mighty spirit in the form of a lucky cat. Madara notices that Natsume bears a remarkable resemblance to his late grandmother Reiko Natsume, an outcast girl who created the Book of Friends. It is now in Natsume's possession.

With no interest in its powers, Natsume decides to keep the book for the sake of his grandmother's memories and to protect it from scheming youkai. Therefore, he makes a deal with Madara: he will hand him the book once his time is up, and in turn, Madara will act as Natsume's unofficial bodyguard. With his newfound goal of freeing those Reiko had sealed, Natsume's relationship with both youkai and humans slowly begins to improve.

というわけで「荒川ＵＢ」第２期製作決定です！！！ 皆様、荒川河川敷の仲間達を引き続き宜しくお願いいたします！

大财团公子哥市之宫行（神谷浩史 配音）自由不知愁滋味，俨然叼着金汤匙出生的金贵少爷，就读于名门学府T大的他即将毕业，未来的人生一片光明，令人欣羡。他铭记市之宫家的家训“不求人，不欠人”，并以此为傲。可是现实的残酷却不得不令他拖欠人情，在开车通过荒川河时，他被几名少年抢走名贵跑车，裤子也被强行扒下挂在桥顶。强逞英雄的阿行爬桥不慎跌落水中，危急时刻被附近的少女小珊（坂本真绫 配音）救助。拖欠了人情的阿行答应作小珊的恋人，他极不情愿地随着这个自称金星人的少女留在荒川河床，并解释了在此生活的一对电波系怪人：河童村长、星星、武士、修女、铁人兄弟等。有趣怪诞的故事就此展开……
本片根据中村光的同名漫画改编。

漫画家久米田康治的超人气连载《再见了,绝望先生》继2007年、2008年相继改编成两部电视动画版，以及讲谈社的特制OAD《狱.再见了,绝望先生》之后，不仅从今年七月番起正式最新一期TVA《忏.再见了,绝望先生》，而且8月16日再度发表崭新的OAD情报。根据官方的消息，全套2集的OAD《忏.再见了,绝望先生 番外地》将于11月17日推出上集，并作为漫画单行本第19卷的初回限定特典OAD来纪念性发售，售价3470日元。目前官网中亦提供了相应的预约登记表以供爱好者们先行订购。这两卷OAD的幕后制作群和声优阵容自然均由原班人马再次出击，绝望先生绝望不断，号称笔下作品这辈子都没办法动画化，跑到天堂也只能看见穿着“草莓棉花糖”T恤的天使的久米田康介，想必现在做梦也会笑出声来吧。

美术大学五人组的故事仍在继续。竹本（神谷浩史 配音）结束了寻找自我的单车之旅，在盛放烟火的晚上对阿久（工藤晴香 配音）说出了那句“我喜欢你。”山田（高桥美佳子 配音）依旧陷在单恋真山（杉田智和 配音）的泥沼中，野宫（滨田贤二 配音）的出现成了泥沼里一株逃脱的稻草；真山则继续追寻着理花（大原沙耶香 配音），胜利的曙光在不远处；森田（上田佑司 配音）和阿久，两个天才的兮兮相惜，能否换来最后的相守。
时间在四季轮回中流逝，微小的变化一点点积攒成为不可忽视的转折点。五人都面临着新的人生，各奔东西。已逝去的奇迹般的岁月，并不会消失，而成为永久的回忆，在内心转动。改编自同名漫画的《蜂蜜与四叶草》故事也走向终点，但对于他们，这则是新的起点。

美术大学学生竹本和学长真山以及多次留级的森田一起生活在单身公寓里，大家的生活风清云淡却也乐趣无穷。
他们的老师花本先生向三人介绍了自己表兄的女儿，阿久。外表幼小的阿久有着惊人的艺术表现力，竹本和森田都不觉得对她一见钟情。难以言表的爱情、友情在三人之间渐渐弥漫。
另一方面，真山爱上了花本老师的朋友理花小姐，而理花却深陷对逝世丈夫的怀念，难以自拔。和真山青梅竹马的山田，在坚强爽朗的个性下却常常因为对真山的单恋而独自落泪。
那个夏季，空气里弥漫着甜蜜也氤氲着苦涩，四叶草在风中摇曳，等待幸福的孩子们采摘。

新房以前就红果果地放出话来：“如果第二季动画DVD卖过了3万张就会考虑再制作第三季TV动画”，于是，他得逞了。
在这个失业率高企、言论被压迫的充满绝望的世界，讲述我们心声的《再见 绝望先生》动画版经历了两季TV动画和OVA之后，又将卷土重来！这次是正式的TV第三季，动画预定在今年7月播出。让我们将绝望进行到底。

由久米田康治原作的《绝望先生》，于2005年开始在讲谈社周刊少年Magazine连载。作品是以12页的独立单元式短篇开展故事，在每一话中，大量渗入对日本的社会现象及自我的嘲讽，并基于作者本身的学识，使用自行创作或特定的词彙，带出有关事件，以及有关的笑点。因此作品内隐藏（或不明显）的物件及文字、让知情者会心微笑的时事材料、诙谐式模彷及笑话的内容，成为作品的最大特色。后来根据本作改编的两季TV动画、在新房昭之监督的带领下更是展现出不失原作风格的魅力。
之前曾推出两部动画版的「绝望先生」，此次迎来了其第三次的动画化。新作标题为「狱・绝望先生」、并决定将以OAD的形式推出。在去年推出的「翼 TOKYO REVELATIONS」OAD版大获成功之后，最近讲谈社旗下的作品推出的OAD初回限定版都是以DVD捆绑漫画来发售，比如即将发售的「魔法先生白之翼」和「校园迷糊大王第三期」，所以此次的「狱・绝望先生」也不会例外。OAD版分为上下两卷，预定于2008年10月17日和2009年2月17日发售，而初回限定版则是分别捆绑漫画第15、16集发售。

无论什么方面都很普通的少女日塔奈美假扮成不上学少女来到学校，却发现学校满是怪人。超乐观少女风浦可符香无论看什么都乐观积极；一板一眼死硬派少女木津千里在“不上学少女为何来学校”这一点与奈美纠缠不清；连班主任糸色望都不上课，忙着自杀。一直认为“普通这个词肯定不是好话”的普通少女奈美，在教室中反倒成了另类。
的确，在被称为“绝望先生”的超消极老师糸色望的带领下，2年へ班全体32人都是有一点儿不正常的人。口头禅是“绝望了！对xx的世界觉悟了”的望，与学生们一起生活的爆笑校园喜剧就这样再次开始了。

樱花飞舞的春天，前往学校途中的少女风浦可符香，发现在樱花树上吊的男子。匆忙之下将男子救下的她，却得到了“真死了怎么办？！”的奇怪质问。面对这名超消极男子，乐观的可符香提出了“上吊的人只是想增高”的无厘头解释，并以“桃色部长”的花名称呼这名男子。
离开男子的风浦可符香来到教室，却发现刚刚见面的男子，正是学校来的新教师——糸色望。因汉字合起来是“绝望”而被学生称为“绝望老师”的望、口头禅是“绝望了！对xx的世界绝望了”。他与2年へ班32名学生的爆笑校园生活就此开始。