Reeling from the death of his girlfriend, Neal struggles to unlock the secret behind a mysterious music box and find Kate’s killer, even as his partnership with Peter begins to crumble.

Charming con man Neal Caffey escapes from a maximum-security prison, only to be recaptured by his nemesis, FBI Agent Peter Burke. With few options, Caffey agrees to help the bureau bring down other elusive criminals in exchange for his eventual freedom. But before long, Caffey finds himself playing a game of cat and mouse with those who want him back in prison or dead.

Facing a fear of starting over with a new therapist, Adrian struggles with his phobias while finding new friends and trying to get back on the force.

Marci Maven is accused of negligent homicide because her neighbor claims that her dog killed his wife. But she claims her dog died a few days ago. So she turns to Monk whom she's obsessed with for help. When he refuses to see her, she buys him at a bachelor auction. When Monk tells her what happened and when he looks a things he discovers a few anomalies.

A TV producer has gotten the idea of developing a movie based off of the events of Monk's capture of Steve Wagner in "Mr. Monk and the Astronaut." They have hired renowned actor David Ruskin to play Monk. However, to get into the role of Monk, Ruskin shadows his character for a couple of days as Monk investigates the linked homicides of a young woman killed in her apartment and a pawnshop owner shot dead during a robbery. However, things get bad when Ruskin gets a little too into the role of Monk.

Monk has stiff competition solving the case of a murdered jewelry store owner from a second-rate PI with a loser reputation who suddenly displays skills even more amazing than Monk's.by:

Monk must reconcile reality with his fan-boy feelings toward an actress who starred as a child in a Brady Bunch-style sitcom in his youth after an attempt on her life.

Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season, is becoming more of a friend to Monk as the series develops, frequently calling him in to help, as much for Monk's benefit as for his own. However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective." Despite flaws and inadequacies all around, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant. From the double-episode pilot through the first half of season three, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk," as she still addresses her new boss.

He’s ingenious, he’s phobic, and he’s obsessive-compulsive. Adrian Monk’s offbeat antics have made him unfit for duty but he’s back as a San Francisco police consultant to help out on their most baffling cases. The brilliant but neurotic Monk is now fighting crime as well as his abnormal fears of germs, heights, crowds and virtually everything else known to man.