Ashitaka, a prince of the disappearing Emishi people, is cursed by a demonized boar god and must journey to the west to find a cure. Along the way, he encounters San, a young human woman fighting to protect the forest, and Lady Eboshi, who is trying to destroy it. Ashitaka must find a way to bring balance to this conflict.

上野树里在结束大河剧拍摄后，为“テレビ東京”电视台拍摄纪录片，探寻日本樱花的起源。途经尼泊尔-喜马拉雅、中国云南省、冲绳、地震灾区岩手等地，历时半年，行程5400公里，体验各地风土人情，感悟樱花与人的羁绊。