Picking up immediately after the events in Resident Evil: Retribution, Alice is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

日军侵华，制造种种人间剧。神秘的魔窟奶人场，使中国妇女陷入深渊；罪恶的X工程国，逼迫女性变为“奶牛”。铁血女儿不堪蹂躏，拿起刀枪与恶魔斗争。血与火的枪战、刀与剑的搏杀：神秘BC与袋鼠的较量……