Yuji Itadori is a boy with tremendous physical strength, though he lives a completely ordinary high school life. One day, to save a classmate who has been attacked by curses, he eats the finger of Ryomen Sukuna, taking the curse into his own soul. From then on, he shares one body with Ryomen Sukuna. Guided by the most powerful of sorcerers, Satoru Gojo, Itadori is admitted to Tokyo Jujutsu High School, an organization that fights the curses... and thus begins the heroic tale of a boy who became a curse to exorcise a curse, a life from which he could never turn back.

全·员·恶·人 犯罪者（恶棍）们的犯罪动作剧开幕！ 遥远的过去，关东和关西之间爆发战争，世界分裂了。关西成为关东的属国，并实现了独立的发展。但相对地，其政治与警力衰退，犯罪横行。这些犯罪者，被称作恶棍—— 本作品的舞台，是高度发达却又高度扭曲的社会。在这样的社会中，恶棍们将会如何以自己的风格生存呢。齐聚一堂的恶棍们的美学，彼此发生碰撞。