Kimihiro Watanuki can see spirits and other assorted supernatural creatures, which is quite a bothersome ability he strongly dislikes. On the way home one day, while plagued by some spirits, he is inexplicably compelled to enter a strange house. There, he encounters Yuuko, a mysterious woman who claims to be able to rid him of the ability to see and attract the troublesome creatures—for a price. She demands that he work at her "store" that grants wishes to people, and thus begins Watanuki's adventures through weird and wonderful events.

吸血猫（小清水亚美 配音）一开始并不是吸血猫，它只是一只普通的，生命垂危的流浪猫，直到它遇见了一个银发的吸血鬼（立花慎之介 配音），它的命运就此改变，嘴里长出了尖牙，背上生出了翅膀，流浪猫以吸血猫的姿态获得了重生。 一次偶然之中，吸血猫被善良的美咲（广田诗梦 配音）收养。吸血猫哥特的外形并没有使美咲敬而远之，正相反，在美咲的家周围，吸血猫很快就结识了一帮各有特色的朋友们。偶像是伊达政宗的政宗猫（杉田纪彰 配音）、被赶出天界的天使猫（福山润 配音）、漂亮的茶茶丸（后藤邑子 配音），有了这些朋友的陪伴，即使变成了吸血鬼，吸血猫也再也不会感到孤单啦。