《我为喜剧狂》于2006年10月11日在美国全国广播公司首播，推出后陆续赢得艾美奖、金球奖等众多奖项。 Liz Lemon（蒂娜·菲 Tina Fey 饰）是当红喜剧秀《The Girlie Show》的首席编剧，可谓如沐春风，前途坦荡。可是旧BOSS因病去世，新上任的Jake（亚历克·鲍德温 Alec Baldwin 饰）是个挑剔的主。刚上任就整出不少事，而节目中的明星演员也带来一堆麻烦。一时间，Liz的问题接踪而至。第一，为了可以保住自己的饭碗；第二，为了保持节目一贯良好的收视率；第三，为了自己能在压力下保持清醒，Liz必须学会克服各种问题，把困难迎刃而解。Liz一帆风顺的生活就这样被打破了，为了让一切都走上正轨，她必须找到一条正确的路......

University physicists Leonard and Sheldon know whether to use an integral or a differential to solve the area under a curve. But they don't have a clue about girls. Or dating. Or clothes. Or parties. Or having fun. Or, basically, life. So when a pretty blonde named Penny moves in the apartment across the hall, the guys decide to get an education outside of the classroom. Boys, you have a lot to learn.