With the world now aware of his dual life as the armored superhero Iron Man, billionaire inventor Tony Stark faces pressure from the government, the press and the public to share his technology with the military. Unwilling to let go of his invention, Stark, with Pepper Potts and James 'Rhodey' Rhodes at his side, must forge new alliances – and confront powerful enemies.

During World War II, Steve Rogers is a sickly man from Brooklyn who's transformed into super-soldier Captain America to aid in the war effort. Rogers must stop the Red Skull – Adolf Hitler's ruthless head of weaponry, and the leader of an organization that intends to use a mysterious device of untold powers for world domination.

Peter Parker is an outcast high schooler abandoned by his parents as a boy, leaving him to be raised by his Uncle Ben and Aunt May. Like most teenagers, Peter is trying to figure out who he is and how he got to be the person he is today. As Peter discovers a mysterious briefcase that belonged to his father, he begins a quest to understand his parents' disappearance – leading him directly to Oscorp and the lab of Dr. Curt Connors, his father's former partner. As Spider-Man is set on a collision course with Connors' alter ego, The Lizard, Peter will make life-altering choices to use his powers and shape his destiny to become a hero.