Two aging crooks are given two weeks to repay a debt to a woman named The American. They recruit their recently deceased partner's son to help them break into a laboratory and steal the vaccine against STBO, a sexually transmitted disease that is sweeping the country. It's spread by having sex without emotional involvement, and most of its victims are teenagers who make love out of curiosity rather than commitment.

The movie, titled “Stitches” (“Coutures”), is set in the world of high fashion and unfolds in Paris. Jolie stars in the movie as a filmmaker and is one of three women whose lives will collide during Fashion Week.

A woman, accidentally caught in a dark deal, turns the tables on her captors and transforms into a merciless warrior evolved beyond human logic.

Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.