A set of six nested stories spanning time between the 19th century and a distant post-apocalyptic future. Cloud Atlas explores how the actions and consequences of individual lives impact one another throughout the past, the present and the future. Action, mystery and romance weave through the story as one soul is shaped from a killer into a hero and a single act of kindness ripples across centuries to inspire a revolution in the distant future. Based on the award winning novel by David Mitchell. Directed by Tom Tykwer and the Wachowskis.

As the railroad builders advance unstoppably through the Arizona desert on their way to the sea, Jill arrives in the small town of Flagstone with the intention of starting a new life.

1916年，阿拉伯大起义爆发。 英军中尉 Lawrence（Peter O'Toole 饰）受命登上阿拉伯半岛之后，决定带领阿拉伯人夺取亚喀巴。在穿越沙漠的过程中， Lawrence 力排众议孤身返回搭救了失踪的 Gasim（I.S. Johar 饰）。此举赢得了众人的尊敬，Ali ibn el Kharish（Omar Sharif 饰）沙里夫甚至让 Lawrence 换上了沙里夫的长袍，而 Lawrence 也欣然接受。可是阿拉伯部落间并不和睦，Harith 部的 Gasim 杀了 Howeitat 部的人，双方剑拔弩张。为了平息争端，Lawrence 亲手处决了 Gasim，而杀人的快感却让 Lawrence 感到不安。成功夺取亚喀巴之后，Lawrence 驼不停蹄地穿越西奈半岛回到开罗。Allenby（Jack Hawkins 饰）将军大喜过望，升 Lawrence 为少校，对其寄予厚望……