口袋妖怪金银 1999年11月21日发售,售价3800日元。在口袋妖怪蓝(青)发售不到两个月任天堂就推出了GB砖头机的更新机型GBP和GBC,同是也在11月21日发售了有色彩的口袋妖怪金银(终于能看到黄黄的皮卡丘了),口袋妖怪金银的发售同样也带动了GBP和GBC的销量.本作从原来的151个精灵增加到251个.地图和剧情也都是全新的。
金银至今都被不少玩家喻为口袋妖怪最高作,其原因和丰富的游戏系统是分不开的,真实时间的加入也让玩家有了更大的代入感.两个版本的口袋妖怪样子都不同,在连动方面不仅两个版本可以联动,还可以和之前的四色联动得到以前的宠物。

真新镇的少年年满10岁之后，就可以得到训练神奇宝贝的资格。10岁的少年小智（松本梨香 配音）以成为最厉害的神奇宝贝训练大师为目标，即将踏上了修行之旅。小智因为早上赖床迟到，险些失去挑选神奇宝贝的资格，无奈下他领走了一只被挑剩下的神奇宝贝——皮卡丘（大谷育江 配音）。皮卡丘又名电气鼠，虽然长相可爱，但性格含羞内向却又不亲近人类，稍有不满就乱放电电人，暴躁的脾气让小智吃尽了苦头。大木博士把神奇宝贝图和宝贝球作为践行礼物送给了小智。在小智和皮卡丘的前方，神奇宝贝的世界有许多谜题和探险在等着他们，迎接他们的到底是光明还是黑暗，小智能否如愿成为神奇宝贝大师呢？

Determined to prove its superiority, a bio-engineered Pokémon called Mewtwo lures Ash, Pikachu and others into a Pokemon match like none before.

The Team Rocket leader, Giovanni, has found Mewtwo in a remote area of the Johto region. As Giovanni tries to re-capture Mewtwo, Ash and his friends are kidnapped by Domino, a new Team Rocket member, while trying to rescue Pikachu from Jessie and James. The Clone Pokemon are also captured and are then used as bait for Mewtwo. The situation then becomes a battle between the wills of Mewtwo and Giovanni; and Mewtwo also tries to discover if it and the clones have a purpose in life, even though they are products of science.

When Lawrence III's scheme to capture the Legendary Pokémon Lugia upsets the balance of nature, it is up to Ash Ketchum and his friends to save the world.

Ash, Pikachu and the gang try and stop a pair of thieves hiding out in the canals and alleyways of Altomare, the age-old water capital. Joining the adventure are two new legendary Pokémon, a pair of siblings named Latias and Latios, who serve as peacekeepers and protectors of the Soul Dew — a priceless treasure with a mysterious power.