关中一个普通的小镇——七俠镇，这里有一家同福客栈。就是这间不起眼的客栈，因缘巧合之下汇聚了一群性格各异又活泼搞怪的年轻人：武功高强但初入江湖的郭芙蓉（姚晨 饰）、老板娘佟湘玉（闫妮 饰）、金盘洗手的神偷白展堂（沙溢 饰）、满腹经纶怀才不遇的吕秀才（喻恩泰 饰）、厨师李大嘴（姜超 饰）等等。这群年轻人在同一屋檐下演绎了一幕幕经典的搞笑场面，在欢笑与眼泪中陪伴观众们一起渐渐成长。

Worlds collide in Season 3! A love affair with Penny has opened a big, wide, wonderful world of romance for Leonard. But Sheldon likes the world just the way it was, thank you. All of which makes for a zany comic triangle with brainy, clueless Sheldon and practical, grounded Penny hilariously vying for the role of hypotenuse.

Whether on or above Earth, hilarity is outrageously universal in TV's most popular comedy featuring four forward-thinking but socially backward geniuses. Fun discoveries multiply: Leonard learns jealousy is bad for a relationship (with Penny) but science is good for seduction (of Penny). Howard finds life in the International Space Station life is no escape from terrestrial turmoil between his mom and his new wife Bernadette. Raj meets someone special who may be a good match, if he can keep her from fleeing mid-date. And then there's Sheldon. He learns what not to say after facing harassment charges or competing for tenure at work and how Dungeons & Dragons can be the icebreaker his relationship with Amy needs.