A grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin, by the prize-winning, bestselling author of Say Nothing
The Sackler name adorns the walls of many storied institutions—Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and the sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing a blockbuster painkiller that was the catalyst for the opioid crisis.
Empire of Pain begins with the story of three doctor brothers, Raymond, Mortimer and the incalculably energetic Arthur, who weathered the poverty of the Great Depression and appalling anti-Semitism. Working at a barbaric mental institution, Arthur saw a better way and conducted groundbreaking research into drug treatments. He also had a genius for marketing, especially for pharmaceuticals, and bought a small ad firm.
Arthur devised the marketing for Valium, and built the first great Sackler fortune. He purchased a drug manufacturer, Purdue Frederick, which would be run by Raymond and Mortimer. The brothers began collecting art, and wives, and grand residences in exotic locales. Their children and grandchildren grew up in luxury.
Forty years later, Raymond’s son Richard ran the family-owned Purdue. The template Arthur Sackler created to sell Valium—co-opting doctors, influencing the FDA, downplaying the drug’s addictiveness—was employed to launch a far more potent product: OxyContin. The drug went on to generate some thirty-five billion dollars in revenue, and to launch a public health crisis in which hundreds of thousands would die.
This is the saga of three generations of a single family and the mark they would leave on the world, a tale that moves from the bustling streets of early twentieth-century Brooklyn to the seaside palaces of Greenwich, Connecticut, and Cap d’Antibes to the corridors of power in Washington, D.C. Empire of Pain chronicles the multiple investigations of the Sacklers and their company, and the scorched-earth legal tactics that the family has used to evade accountability. The history of the Sackler dynasty is rife with drama—baroque personal lives; bitter disputes over estates; fistfights in boardrooms; glittering art collections; Machiavellian courtroom maneuvers; and the calculated use of money to burnish reputations and crush the less powerful.
Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling. It is a portrait of the excesses of America’s second Gilded Age, a study of impunity among the super elite and a relentless investigation of the naked greed and indifference to human suffering that built one of the world’s great fortunes.

Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true?
Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.
The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings?
A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

Book Description
Frankl's timeless memoir and meditation on finding meaning in the midst of suffering With a new Foreword by Harold S. Kushner and a new Biographical Afterword by William J. Winslade Psychiatrist Viktor Frankl's memoir has riveted generations of readers with its descriptions of life in Nazi death camps and its lessons for spiritual survival. Between 1942 and 1945 Frankl labored in four different camps, including Auschwitz, while his parents, brother, and pregnant wife perished. Based on his own experience and the experiences of others he treated later in his practice, Frankl argues that we cannot avoid suffering but we can choose how to cope with it, find meaning in it, and move forward with renewed purpose. Frankl's theory-known as logotherapy, from the Greek word logos ("meaning")-holds that our primary drive in life is not pleasure, as Freud maintained, but the discovery and pursuit of what we personally find meaningful. At the time of Frankl's death in 1997, Man's Search for Meaning had sold more than 10 million copies in twenty-four languages. A 1991 reader survey for the Library of Congress that asked readers to name a "book that made a difference in your life" found Man's Search for Meaning among the ten most influential books in America. Beacon Press, the original English-language publisher of Man's Search for Meaning, is issuing this new paperback edition with a new Foreword, biographical Afterword, jacket, price, and classroom materials to reach new generations of readers.
Book Dimension
length: (cm)17.6 　　　 　　　　　 　　　　　 width:(cm)10.6

The bestselling author of Seven Brief Lessons on Physics takes us on an enchanting, consoling journey to discover the meaning of time
'We are time. We are this space, this clearing opened by the traces of memory inside the connections between our neurons. We are memory. We are nostalgia. We are longing for a future that will not come.'
Time is a mystery that does not cease to puzzle us. Philosophers, artists and poets have long explored its meaning while scientists have found that its structure is different from the simple intuition we have of it. From Boltzmann to quantum theory, from Einstein to loop quantum gravity, our understanding of time has been undergoing radical transformations. Time flows at a different speed in different places, the past and the future differ far less than we might think, and the very notion of the present evaporates in the vast universe.
With his extraordinary charm and sense of wonder, bringing together science, philosophy and art, Carlo Rovelli unravels this mystery. Enlightening and consoling, The Order of Time shows that to understand ourselves we need to reflect on time -- and to understand time we need to reflect on ourselves.

In this urgent, authoritative book, Bill Gates sets out a wide-ranging, practical--and accessible--plan for how the world can get to zero greenhouse gas emissions in time to avoid a climate catastrophe.
Bill Gates has spent a decade investigating the causes and effects of climate change. With the help of experts in the fields of physics, chemistry, biology, engineering, political science, and finance, he has focused on what must be done in order to stop the planet's slide toward certain environmental disaster. In this book, he not only explains why we need to work toward net-zero emissions of greenhouse gases, but also details what we need to do to achieve this profoundly important goal.
He gives us a clear-eyed description of the challenges we face. Drawing on his understanding of innovation and what it takes to get new ideas into the market, he describes the areas in which technology is already helping to reduce emissions, where and how the current technology can be made to function more effectively, where breakthrough technologies are needed, and who is working on these essential innovations. Finally, he lays out a concrete, practical plan for achieving the goal of zero emissions--suggesting not only policies that governments should adopt, but what we as individuals can do to keep our government, our employers, and ourselves accountable in this crucial enterprise.
As Bill Gates makes clear, achieving zero emissions will not be simple or easy to do, but if we follow the plan he sets out here, it is a goal firmly within our reach.

At the end of the Second World War, Cyril Conroy combines luck and a single canny investment to begin an enormous real estate empire, propelling his family from poverty to enormous wealth. His first order of business is to buy the Dutch House, a lavish estate in the suburbs outside of Philadelphia. Meant as a surprise for his wife, the house sets in motion the undoing of everyone he loves.
The story is told by Cyril’s son Danny, as he and his older sister, the brilliantly acerbic and self-assured Maeve, are exiled from the house where they grew up by their stepmother. The two wealthy siblings are thrown back into the poverty their parents had escaped from and find that all they have to count on is one another. It is this unshakeable bond between them that both saves their lives and thwarts their futures.
Set over the course of five decades, The Dutch House is a dark fairy tale about two smart people who cannot overcome their past. Despite every outward sign of success, Danny and Maeve are only truly comfortable when they’re together. Throughout their lives they return to the well-worn story of what they’ve lost with humor and rage. But when at last they’re forced to confront the people who left them behind, the relationship between an indulged brother and his ever-protective sister is finally tested.

NATIONAL BESTSELLER • LONGLISTED FOR THE MAN BOOKER PRIZE • NAMED ONE OF THE BEST BOOKS OF THE YEAR BY THE WASHINGTON POST
Meet Harold Fry, recently retired. He lives in a small English village with his wife, Maureen, who seems irritated by almost everything he does, even down to how he butters his toast. Little differentiates one day from the next. Then one morning the mail arrives, and within the stack of quotidian minutiae is a letter addressed to Harold in a shaky scrawl from a woman he hasn’t seen or heard from in twenty years. Queenie Hennessy is in hospice and is writing to say goodbye.

Harold pens a quick reply and, leaving Maureen to her chores, heads to the corner mailbox. But then, as happens in the very best works of fiction, Harold has a chance encounter, one that convinces him that he absolutely must deliver his message to Queenie in person. And thus begins the unlikely pilgrimage at the heart of Rachel Joyce’s remarkable debut. Harold Fry is determined to walk six hundred miles from Kingsbridge to the hospice in Berwick-upon-Tweed because, he believes, as long as he walks, Queenie Hennessey will live.

Still in his yachting shoes and light coat, Harold embarks on his urgent quest across the countryside. Along the way he meets one fascinating character after another, each of whom unlocks his long-dormant spirit and sense of promise. Memories of his first dance with Maureen, his wedding day, his joy in fatherhood, come rushing back to him—allowing him to also reconcile the losses and the regrets. As for Maureen, she finds herself missing Harold for the first time in years.

And then there is the unfinished business with Queenie Hennessy.

A novel of unsentimental charm, humor, and profound insight into the thoughts and feelings we all bury deep within our hearts, The Unlikely Pilgrimage of Harold Fry introduces Rachel Joyce as a wise—and utterly irresistible—storyteller.
Advance praise for The Unlikely Pilgrimage of Harold Fry

“When it seems almost too late, Harold Fry opens his battered heart and lets the world rush in. This funny, poignant story about an ordinary man on an extraordinary journey moved and inspired me.”—Nancy Horan, author of Loving Frank

“There’s tremendous heart in this debut novel by Rachel Joyce, as she probes questions that are as simple as they are profound: Can we begin to live again, and live truly, as ourselves, even in middle age, when all seems ruined? Can we believe in hope when hope seems to have abandoned us? I found myself laughing through tears, rooting for Harold at every step of his journey. I’m still rooting for him.”—Paula McLain, author of The Paris Wife

“Marvelous! I held my breath at his every blister and cramp, and felt as if by turning the pages, I might help his impossible quest succeed.”—Helen Simonson, author of Major Pettigrew’s Last Stand

“Harold’s journey is ordinary and extraordinary; it is a journey through the self, through modern society, through time and landscape. It is a funny book, a wise book, a charming book—but never cloying. It’s a book with a savage twist—and yet never seems manipulative. Perhaps because Harold himself is just wonderful. . . . I’m telling you now: I love this book.”—Erica Wagner, The Times (UK)

“The odyssey of a simple man . . . original, subtle and touching.”—Claire Tomalin, author of Charles Dickens: A Life

Duration: 11:34:06
AN INSTANT #1 NEW YORK TIMES BESTSELLER
A GOOD MORNING AMERICA Book Club Pick!
"Bennett's tone and style recalls James Baldwin and Jacqueline Woodson, but it's especially reminiscent of Toni Morrison's 1970 debut novel, The Bluest Eye." —Kiley Reid, Wall Street Journal
"A story of absolute, universal timelessness ...For any era, it's an accomplished, affecting novel. For this moment, it's piercing, subtly wending its way toward questions about who we are and who we want to be...." – Entertainment Weekly
From The New York Times-bestselling author of The Mothers, a stunning new novel about twin sisters, inseparable as children, who ultimately choose to live in two very different worlds, one black and one white.
The Vignes twin sisters will always be identical. But after growing up together in a small, southern black community and running away at age sixteen, it's not just the shape of their daily lives that is different as adults, it's everything: their families, their communities, their racial identities. Many years later, one sister lives with her black daughter in the same southern town she once tried to escape. The other secretly passes for white, and her white husband knows nothing of her past. Still, even separated by so many miles and just as many lies, the fates of the twins remain intertwined. What will happen to the next generation, when their own daughters' storylines intersect?
Weaving together multiple strands and generations of this family, from the Deep South to California, from the 1950s to the 1990s, Brit Bennett produces a story that is at once a riveting, emotional family story and a brilliant exploration of the American history of passing. Looking well beyond issues of race, The Vanishing Half considers the lasting influence of the past as it shapes a person's decisions, desires, and expectations, and explores some of the multiple reasons and realms in which people sometimes feel pulled to live as something other than their origins.
As with her New York Times-bestselling debut The Mothers, Brit Bennett offers an engrossing page-turner about family and relationships that is immersive and provocative, compassionate and wise.

Klara and the Sun, the first novel by Kazuo Ishiguro since he was awarded the Nobel Prize in Literature, tells the story of Klara, an Artificial Friend with outstanding observational qualities, who, from her place in the store, watches carefully the behavior of those who come in to browse, and of those who pass on the street outside. She remains hopeful a customer will soon choose her.
Klara and the Sun is a thrilling book that offers a look at our changing world through the eyes of an unforgettable narrator, and one that explores the fundamental question: what does it mean to love?

The only thing wrong with this readable, funny memoir of a magazine writer's yearlong travels across the world in search of pleasure and balance is that it seems so much like a Jennifer Aniston movie. Like Jen, Liz is a plucky blond American woman in her thirties with no children and no major money worries. As the book opens, she is going through a really bad divorce and subsequent stormy rebound love affair. Awash in tears in the middle of the night on the floor of the bathroom, she begins to pray for guidance, “you know —— like, to God.” God answers. He tells her to go back to bed. I started seeing the Star headlines： “Jen's New Faith！” “What Really Happened at the Ashram！” “Jen's Brazilian Sugar Daddy —— Exclusive Photos！” Please understand that Gilbert, whose earlier nonfiction book, The Last American Man, portrayed a contemporary frontiersman, is serious about her quest. But because she never leaves her self-deprecating humor at home, her journey out of depression and toward belief lacks a certain gravitas. The book is composed of 108 short chapters (based on the beads in a traditional Indian japa mala prayer necklace) that often come across as scenes in a movie. And however sad she feels or however deeply she experiences something, she can't seem to avoid dressing up her feelings in prose that can get too cute and too trite. On the other hand, she convinced me that she acquired more wisdom than most young American seekers —— and did it without peyote buttons or other classic hippie medicines. When Gilbert determines that she requires a year of healing, her first stop is Italy, because she feels she needs to immerse herself in a language and culture that worships pleasure and beauty. This sets the stage for a “Jen's Romp in Rome,” where she studies Italian and, with newfound friends, searches for the best pizza in the world......

"Toad," the famous character in Kenneth Grahame's Wind in the Willows, is in a very depressed state. "Now look here Toad, this can go on no longer,' he [Badger] said sternly. "There is only one thing left. You must have Counselling!" Robert de Board's engaging account of Toad's experience in counseling will capture the imagination of the growing readership of those interested in counseling theory and practice. The ten chapters of the book are played as the ten sessions which help Toad to self-analysis and personal development. In portraying Heron as a counselor employing the theories of Transactional Analysis in therapy, the author demonstrates how theory is used in practice.

From the bestselling author of Alias Grace and the MaddAddam trilogy, here is the #1 New York Times bestseller and seminal work of speculative fiction from the Booker Prize-winning author.
Now a Hulu series starring Elizabeth Moss, Samira Wiley, and Joseph Fiennes. Includes a new introduction by Margaret Atwood.
Offred is a Handmaid in the Republic of Gilead. She may leave the home of the Commander and his wife once a day to walk to food markets whose signs are now pictures instead of words because women are no longer allowed to read. She must lie on her back once a month and pray that the Commander makes her pregnant, because in an age of declining births, Offred and the other Handmaids are valued only if their ovaries are viable.
Offred can remember the days before, when she lived and made love with her husband Luke; when she played with and protected her daughter; when she had a job, money of her own, and access to knowledge. But all of that is gone now….
Funny, unexpected, horrifying, and altogether convincing, The Handmaid's Tale is at once scathing satire, dire warning, and literary tour de force.

A timely examination by a leading scientist of the physical, psychological, and moral effects of inequality.
The levels of inequality in the world today are on a scale that have not been seen in our lifetimes, yet the disparity between rich and poor has ramifications that extend far beyond mere financial means. In The Broken Ladder psychologist Keith Payne examines how inequality divides us not just economically; it also has profound consequences for how we think, how we respond to stress, how our immune systems function, and even how we view moral concepts such as justice and fairness.
Research in psychology, neuroscience, and behavioral economics has not only revealed important new insights into how inequality changes people in predictable ways but also provided a corrective to the flawed view of poverty as being the result of individual character failings. Among modern developed societies, inequality is not primarily a matter of the actual amount of money people have. It is, rather, people's sense of where they stand in relation to others. Feeling poor matters—not just being poor. Regardless of their average incomes, countries or states with greater levels of income inequality have much higher rates of all the social maladies we associate with poverty, including lower than average life expectancies, serious health problems, mental illness, and crime.
The Broken Ladder explores such issues as why women in poor societies often have more children, and why they have them at a younger age; why there is little trust among the working class in the prudence of investing for the future; why people's perception of their social status affects their political beliefs and leads to greater political divisions; how poverty raises stress levels as effectively as actual physical threats; how inequality in the workplace affects performance; and why unequal societies tend to become more religious. Understanding how inequality shapes our world can help us better understand what drives ideological divides, why high inequality makes the middle class feel left behind, and how to disconnect from the endless treadmill of social comparison.

Promising to be the debut novel of the season The Silent Patient is a shocking psychological thriller of a woman’s act of violence against her husband—and of the therapist obsessed with uncovering her motive…
Alicia Berenson’s life is seemingly perfect. A famous painter married to an in-demand fashion photographer, she lives in a grand house with big windows overlooking a park in one of London’s most desirable areas. One evening her husband Gabriel returns home late from a fashion shoot, and Alicia shoots him five times in the face, and then never speaks another word.
Alicia’s refusal to talk, or give any kind of explanation, turns a domestic tragedy into something far grander, a mystery that captures the public imagination and casts Alicia into notoriety. The price of her art skyrockets, and she, the silent patient, is hidden away from the tabloids and spotlight at the Grove, a secure forensic unit in North London.
Theo Faber is a criminal psychotherapist who has waited a long time for the opportunity to work with Alicia. His determination to get her to talk and unravel the mystery of why she shot her husband takes him down a twisting path into his own motivations—a search for the truth that threatens to consume him....

'It's such a great read...I got to 800 pages, and I slowed myself down because I didn't want it to end.' --This text refers to the Paperback edition.

Bill Bryson, bestselling author of A Short History of Nearly Everything, takes us on a head-to-toe tour of the marvel that is the human body. As addictive as it is comprehensive, this is Bryson at his very best, a must-read owner's manual for everybody.
Bill Bryson once again proves himself to be an incomparable companion as he guides us through the human body--how it functions, its remarkable ability to heal itself, and (unfortunately) the ways it can fail. Full of extraordinary facts (your body made a million red blood cells since you started reading this) and irresistible Bryson-esque anecdotes, The Body will lead you to a deeper understanding of the miracle that is life in general and you in particular. As Bill Bryson writes, "We pass our existence within this wobble of flesh and yet take it almost entirely for granted." The Body will cure that indifference with generous doses of wondrous, compulsively readable facts and information.

She was known to the world as Emily Doe when she stunned millions with a letter. Brock Turner had been sentenced to just six months in county jail after he was found sexually assaulting her on Stanford's campus. Her victim impact statement was posted on BuzzFeed, where it instantly went viral--viewed by eleven million people within four days, it was translated globally and read on the floor of Congress; it inspired changes in California law and the recall of the judge in the case. Thousands wrote to say that she had given them the courage to share their own experiences of assault for the first time.
Now she reclaims her identity to tell her story of trauma, transcendence, and the power of words. It was the perfect case, in many ways--there were eyewitnesses, Turner ran away, physical evidence was immediately secured. But her struggles with isolation and shame during the aftermath and the trial reveal the oppression victims face in even the best-case scenarios. Her story illuminates a culture biased to protect perpetrators, indicts a criminal justice system designed to fail the most vulnerable, and, ultimately, shines with the courage required to move through suffering and live a full and beautiful life.
Know My Name will forever transform the way we think about sexual assault, challenging our beliefs about what is acceptable and speaking truth to the tumultuous reality of healing. It also introduces readers to an extraordinary writer, one whose words have already changed our world. Entwining pain, resilience, and humor, this memoir will stand as a modern classic.

Welcome to colorful Trenton, New Jersey, and the wild and wonderful world of Stephanie Plum. In One for the Money, rookie "apprehension agent" Plum may be a bit wet behind the ears, but nobody's gonna take it easy on her; especially her first skip, an ex-cop and murder suspect named Morelli.

For readers of Atul Gawande, Andrew Solomon, and Anne Lamott, a profoundly moving, exquisitely observed memoir by a young neurosurgeon faced with a terminal cancer diagnosis who attempts to answer the question What makes a life worth living?
At the age of thirty-six, on the verge of completing a decade’s worth of training as a neurosurgeon, Paul Kalanithi was diagnosed with stage IV lung cancer. One day he was a doctor treating the dying, and the next he was a patient struggling to live. And just like that, the future he and his wife had imagined evaporated. When Breath Becomes Air chronicles Kalanithi’s transformation from a naïve medical student “possessed,” as he wrote, “by the question of what, given that all organisms die, makes a virtuous and meaningful life” into a neurosurgeon at Stanford working in the brain, the most critical place for human identity, and finally into a patient and new father confronting his own mortality.
What makes life worth living in the face of death? What do you do when the future, no longer a ladder toward your goals in life, flattens out into a perpetual present? What does it mean to have a child, to nurture a new life as another fades away? These are some of the questions Kalanithi wrestles with in this profoundly moving, exquisitely observed memoir.
Paul Kalanithi died in March 2015, while working on this book, yet his words live on as a guide and a gift to us all. “I began to realize that coming face to face with my own mortality, in a sense, had changed nothing and everything,” he wrote. “Seven words from Samuel Beckett began to repeat in my head: ‘I can’t go on. I’ll go on.’” When Breath Becomes Air is an unforgettable, life-affirming reflection on the challenge of facing death and on the relationship between doctor and patient, from a brilliant writer who became both.

An incredible memoir from one of the world’s most eminent heart surgeons and some of the most remarkable and poignant cases he’s worked on.
Grim Reaper sits on the heart surgeon’s shoulder. A slip of the hand and life ebbs away.
The balance between life and death is so delicate, and the heart surgeon walks that rope between the two. In the operating room there is no time for doubt. It is flesh, blood, rib-retractors and pumping the vital organ with your bare hand to squeeze the life back into it. An off-day can have dire consequences – this job has a steep learning curve, and the cost is measured in human life. Cardiac surgery is not for the faint of heart.
Professor Stephen Westaby took chances and pushed the boundaries of heart surgery. He saved hundreds of lives over the course of a thirty-five year career and now, in his astounding memoir, Westaby details some of his most remarkable and poignant cases – such as the baby who had suffered multiple heart attacks by six months old, a woman who lived the nightmare of locked-in syndrome, and a man whose life was powered by a battery for eight years.
A powerful, important and incredibly moving book, Fragile Lives offers an exceptional insight into the exhilarating and sometimes tragic world of heart surgery, and how it feels to hold someone’s life in your hands.