In the future, an outbreak of canine flu leads the mayor of a Japanese city to banish all dogs to an island used as a garbage dump. The outcasts must soon embark on an epic journey when a 12-year-old boy arrives on the island to find his beloved pet.

When her grandson is kidnapped during the Tour de France, Madame Souza and her beloved pooch Bruno team up with the Belleville Sisters—an aged song-and-dance team from the days of Fred Astaire—to rescue him.