贝斯（金妮弗·古德温 Ginnifer Goodwin 饰）从小的梦想就是能够成为一名家庭主妇，如今她嫁给了罗伯特（山姆·贾格 Sam Jaeger 饰）为妻，总算是实现了理想。没想到第三者的出现将她美好的生活幻影撕成了碎片。 社交名媛西蒙尼（刘玉玲 饰）嫁给了非常疼爱她的卡尔（杰克·达文波特 Jack Davenport 饰），哪知道竟然在偶然之中发现卡尔竟然是一名同性恋者，在守住秘密和守住尊严之间，西蒙尼必须做出选择。 泰勒（柯尔比·豪威尔-巴普蒂斯特 Kirby Howell-Baptiste 饰）和埃里（瑞德·斯科特 Reid Scott 饰）正在进行一场开放式婚姻，泰勒的情人杰德（亚历珊德拉·达达里奥 Alexandra Daddario 饰）的出现让埃里开始觉得，在他们两个人里面再加一个人似乎也是个不错的主意。

This season, Leonard gets a girl. So does Sheldon. Howard drives the Mars Rover into a ditch. Raj woos a terminator. Gorgeous girl-next-door Penny falls under the spell of Age of Conan. And super-smart, ueberconfident Leslie Winkler reduces mere men to spineless jellyfish.

University physicists Leonard and Sheldon know whether to use an integral or a differential to solve the area under a curve. But they don't have a clue about girls. Or dating. Or clothes. Or parties. Or having fun. Or, basically, life. So when a pretty blonde named Penny moves in the apartment across the hall, the guys decide to get an education outside of the classroom. Boys, you have a lot to learn.