A stranger stumbles into the desert town of Absolution with no memory of his past and a futuristic shackle around his wrist. With the help of mysterious beauty Ella and the iron-fisted Colonel Dolarhyde, he finds himself leading an unlikely posse of cowboys, outlaws, and Apache warriors against a common enemy from beyond this world in an epic showdown for survival.

Set during the Cold War, the Soviets—led by sword-wielding Irina Spalko—are in search of a crystal skull which has supernatural powers related to a mystical Lost City of Gold. Indy is coerced to head to Peru at the behest of a young man whose friend—and Indy's colleague—Professor Oxley has been captured for his knowledge of the skull's whereabouts.

After arriving in India, Indiana Jones is asked by a desperate village to find a mystical stone. He agrees – and stumbles upon a secret cult plotting a terrible plan in the catacombs of an ancient palace.