主人公史达琳，年轻娇小却冷静聪慧，意志坚定，她从上司那儿接受了缉拿性变态杀人犯“野牛比尔”的任务。为了了解案犯的心理，她向邪恶的天才莱克特医生寻找线索，与这个残忍的杀人犯展开殊死捕斗……

Clarice Starling is a top student at the FBI's training academy. Jack Crawford wants Clarice to interview Dr. Hannibal Lecter, a brilliant psychiatrist who is also a violent psychopath, serving life behind bars for various acts of murder and cannibalism. Crawford believes that Lecter may have insight into a case and that Starling, as an attractive young woman, may be just the bait to draw him out.