Real zombies arrive and terrorize the crew of a zombie film being shot in an abandoned warehouse, said to be the site of military experiments on humans.

Life for former United Nations investigator Gerry Lane and his family seems content. Suddenly, the world is plagued by a mysterious infection turning whole human populations into rampaging mindless zombies. After barely escaping the chaos, Lane is persuaded to go on a mission to investigate this disease. What follows is a perilous trek around the world where Lane must brave horrific dangers and long odds to find answers before human civilization falls.

瑞克带领大家离开了亚特兰大。在高速公路上，他们被一种前所未有的威胁拦了下来。大家在寻找一个失踪的人。