England, 1600. Queen Elizabeth I promises Orlando, a young nobleman obsessed with poetry, that she will grant him land and fortune if he agrees to satisfy a very particular request.

Two sisters move to the country with their father in order to be closer to their hospitalized mother, and discover the surrounding trees are inhabited by Totoros, magical spirits of the forest. When the youngest runs away from home, the older sister seeks help from the spirits to find her.

In 2071, roughly fifty years after an accident with a hyperspace gateway made the Earth almost uninhabitable, humanity has colonized most of the rocky planets and moons of the Solar System. Amid a rising crime rate, the Inter Solar System Police (ISSP) set up a legalized contract system, in which registered bounty hunters, also referred to as "Cowboys", chase criminals and bring them in alive in return for a reward.

Eccentric consulting detective Sherlock Holmes and Doctor John Watson battle to bring down a new nemesis and unravel a deadly plot that could destroy England.