NYPD cop John McClane's plan to reconcile with his estranged wife is thrown for a serious loop when, minutes after he arrives at her office, the entire building is overtaken by a group of terrorists. With little help from the LAPD, wisecracking McClane sets out to single-handedly rescue the hostages and bring the bad guys down.

Life for former United Nations investigator Gerry Lane and his family seems content. Suddenly, the world is plagued by a mysterious infection turning whole human populations into rampaging mindless zombies. After barely escaping the chaos, Lane is persuaded to go on a mission to investigate this disease. What follows is a perilous trek around the world where Lane must brave horrific dangers and long odds to find answers before human civilization falls.