Factory worker Doug Quaid takes a virtual mind-trip vacation with the Rekall company, opting for implanted memories of being a spy. When the procedure goes wrong, Quaid becomes a wanted man by the police and joins forces with a rebel fighter to stop the evil Chancellor Cohaagen.

Having escaped years of imprisonment, vampire warrioress Selene finds herself in a changed world where humans have discovered the existence of both Vampire and Lycan clans and are conducting an all-out war to eradicate both immortal species. Now Selene must battle the humans and a frightening new breed of super Lycans to ensure the death dealers' survival.