A Texan traveling across the wild West bringing the news of the world to local townspeople, agrees to help rescue a young girl who was kidnapped.

Ride with the Devil follows four people who are fighting for truth and justice amidst the turmoil of the American Civil War. Director Ang Lee takes us to a no man's land on the Missouri/Kansas border where a staunch loyalist, an immigrant's son, a freed slave, and a young widow form an unlikely friendship as they learn how to survive in an uncertain time. In a place without rules and redefine the meaning of bravery and honor.

In this classic story of love and devotion set against the backdrop of the American Civil War, a wounded Confederate soldier named W.P. Inman deserts his unit and travels across the South, aiming to return to his young wife, Ada, who he left behind to tend their farm. As Inman makes his perilous journey home, Ada struggles to keep their home intact with the assistance of Ruby, a mysterious drifter sent to help her by a kindly neighbor.