Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

Lola receives a phone call from her boyfriend Manni. He lost 100,000 DM in a subway train that belongs to a very bad guy. She has 20 minutes to raise this amount and meet Manni. Otherwise, he will rob a store to get the money. Three different alternatives may happen depending on some minor event along Lola's run.

An acclaimed novelist struggles to write an analysis of love in one of three stories, each set in a different city, that detail the beginning, middle and end of a relationship.