Clarice Starling is a top student at the FBI's training academy. Jack Crawford wants Clarice to interview Dr. Hannibal Lecter, a brilliant psychiatrist who is also a violent psychopath, serving life behind bars for various acts of murder and cannibalism. Crawford believes that Lecter may have insight into a case and that Starling, as an attractive young woman, may be just the bait to draw him out.

A husband is on trial for the attempted murder of his wife, in what is seemingly an open/shut case for the ambitious district attorney trying to put him away. However, there are surprises for both around every corner, and, as a suspenseful game of cat-and-mouse is played out, each must manipulate and outwit the other.