A bouncer with an anger management problem goes on a furious and resentful rampage after the murder of a friend.

Filmed in 1993 but never completed due to River Phoenix's death, Dark Blood tells the story of Boy, a young widower living on a nuclear testing site in the desert. Boy is waiting for the end of the world and carves Katchina dolls that supposedly contain magical powers. Boy's solitude is interrupted when a Hollywood jet-set couple who are travelling across the desert become stranded after their car breaks down. The couple are rescued by Boy, who then holds them prisoner because of his desire for the woman and his ambition to create a better world with her.

After seven months have passed without a culprit in her daughter's murder case, Mildred Hayes makes a bold move, painting three signs leading into her town with a controversial message directed at Bill Willoughby, the town's revered chief of police. When his second-in-command Officer Jason Dixon, an immature mother's boy with a penchant for violence, gets involved, the battle between Mildred and Ebbing's law enforcement is only exacerbated.

Injustice and the demands of the world can cause stress for many people. Some of them, however, explode. This includes a waitress serving a grouchy loan shark, an altercation between two motorists, an ill-fated wedding reception, and a wealthy businessman who tries to buy his family out of trouble.