Doctor Strange, with the help of mystical allies both old and new, traverses the mind-bending and dangerous alternate realities of the Multiverse to confront a mysterious new adversary.

Dangerously ill with a rare blood disorder, and determined to save others suffering his same fate, Dr. Michael Morbius attempts a desperate gamble. What at first appears to be a radical success soon reveals itself to be a remedy potentially worse than the disease.

Investigative journalist Eddie Brock attempts a comeback following a scandal, but accidentally becomes the host of Venom, a violent, super powerful alien symbiote. Soon, he must rely on his newfound powers to protect the world from a shadowy organization looking for a symbiote of their own.

As the Avengers and their allies have continued to protect the world from threats too large for any one hero to handle, a new danger has emerged from the cosmic shadows: Thanos. A despot of intergalactic infamy, his goal is to collect all six Infinity Stones, artifacts of unimaginable power, and use them to inflict his twisted will on all of reality. Everything the Avengers have fought for has led up to this moment - the fate of Earth and existence itself has never been more uncertain.

After his career is destroyed, a brilliant but arrogant surgeon gets a new lease on life when a sorcerer takes him under her wing and trains him to defend the world against evil.