Clairvoyant femme fatale Nicola Six has been living with a dark premonition of her impending death by murder. She begins a tangled love affair with three uniquely different men: one of whom she knows will be her murderer.

George Lutz, his wife Kathy, and their three children have just moved into a beautiful, and improbably cheap, Dutch colonial mansion nestled in the sleepy coastal town of Amityville, Long Island. However, their dream home is concealing a horrific past and soon each member of the Lutz family is plagued with increasingly strange and violent visions and impulses.