The few remaining Salem descendants are under assault by forces of ignorance and hate. The young witches seek refuge at Miss Robichaux's Academy in New Orleans, including new arrival, Zoe, who harbors a terrifying secret of her own. Fiona, a Supreme Witch with unimaginable powers, is determined to protect the Coven, but her obsessive quest for immortality will lead her to cross paths with a voodoo queen and a murderous slave owner cursed with eternal life.

From Nazis and serial killers to mutants and aliens, no one is safe inside the walls of the Briarcliff Mental Institution. In a house of healing that is anything but, troubled nun Sister Jude rules with an iron fist and Dr Arden conducts strange experiments on the facility’s patients.