故事发生在遥远的未来世界，此时，人类对于太空的勘探已经发展到了成熟的阶段，梅尔（内森·菲利安 Nathan Fillion 饰）是太空船“宁静号”的船长，每一日，梅尔都驾驶着他的“家”，穿梭在浩瀚的宇宙之中。 宁静号拥有九名乘客，这九人地位悬殊，个性迥异，每一个人都有着一段不可告人的灰暗往事，而他们脱离陆地登上宁静号，亦有着各自不同的理由。九人唯一的共同点在于，他们都是地上世界中的“刺头”。为了维持生计，宁静号接纳一切能够赚钱的任务，其中甚至有些看起来并不是那么合法，与此同时，梅尔船长亦要带领他的船员们设法逃脱联邦政府的追踪。

The career of screenwriter Dalton Trumbo is halted by a witch hunt in the late 1940s when he defies the anti-communist HUAC committee and is blacklisted.

A myriad of outrageous calamities befalls an eccentric English clan with more than a few skeletons in its closets when the family's patriarch dies an unexpected death.

When the renegade crew of Serenity agrees to hide a fugitive on their ship, they find themselves in an action-packed battle between the relentless military might of a totalitarian regime who will destroy anything – or anyone – to get the girl back and the bloodthirsty creatures who roam the uncharted areas of space. But... the greatest danger of all may be on their ship.