Agent Jack Ryan becomes acting Deputy Director of Intelligence for the CIA when Admiral Greer is diagnosed with cancer. When an American businessman, and friend of the president, is murdered on his yacht, Ryan starts discovering links between the man and drug dealers. As former CIA agent John Clark is sent to Colombia to kill drug cartel kingpins in retaliation, Ryan must fight through multiple cover-ups to figure out what happened and who's responsible.

On his first day after being released from jail for 14 armed bank robberies, Lucas finds himself caught up in someone else's robbery. Perry has decided to hold up the local bank to raise money so that he can keep his daughter, Meg, and get her the treatment she needs. Dugan, a detective, assumes Lucas helped plan the robbery, and hence Lucas, Perry and Meg become three fugitives.